Last Frontier

Last Frontier

Adolescence: the last frontier.

Aortic dissection. The last frontier.

Aortic dissection is a medical or surgical emergency, or both, that is catastrophic if not diagnosed and treated promptly. It is the most common aortic pathological lesion in the United States warranting emergent diagnosis and treatment. In untreated or unrecognized patients with aortic dissection, the prognosis is decidedly dismal, with the early mortality (first 48 hours) being as high as 1%/...

Breast cancer brain metastases: the last frontier

Breast cancer is a common cause of brain metastases, with metastases occurring in at least 10-16 % of patients. Longer survival of patients with metastatic breast cancer and the use of better imaging techniques are associated with an increased incidence of brain metastases. Unfortunately, patients who develop brain metastases tend to have poor prognosis with short overall survival. In addition,...

Orthostatic hypertension: the last hemodynamic frontier.

Orthostatic hypertension (OHT) is beneath the radar of many health care professionals. In the clinic, it is generally both unexpected and counterintuitive. After recheck, it may sometimes regress toward the mean. However, at other times the OHT can be dramatic and persistent. Nevertheless, our knowledge about its causes and significance remains circumscribed. It is in many ways the last hemodyn...